• Oral prolonged release tablet
• Mode of Action:
  • The exact way that Mysimba works is not fully understood, but the two active substances, naltrexone (a mu-opioid antagonist) and bupropion (a weak inhibitor of neuronal dopamine and norepinephrine reuptake), act on: 
    1.The hypothalamus to control food intake and energy balance.
    2. The mesolimbic dopaminergic reward system controling the pleasure associated with eating.
  • When given together, their additive effect reduces appetite and the amount that customers eat.
  • Coupled with an increased energy expenditure and calorie-controlled diet, this helps to reduce body weight.⁵
• Dose:
  • Titrated up to two twice a day over 4 weeks. Start with one tablet daily increasing by one tablet each week until maintenance dose achieved.
  • Treatment should be discontinued after 16 weeks if customer has not lost at least 5% of their initial body weight.
• Side effects include:
  • Nausea, vomiting, diarrhoea, headache, anxiety, dizziness, fatigue, difficulty sleeping and irritability.

Not currently available on the NHS.

^{5 Mysimba SPC}