Norethisterone should only be given if it is safe for that patient, a list of contra-indications include:

• Hypersensitivity to the active ingredient or any of the excipients.
• Pregnancy
• Previous idiopathic or current venous thromboembolism (DVT or PE)
• Active or recent arterial thromboembolic disease (e.g. MI or Angina)
• Disturbance of liver function
• History of idiopathic jaundice during pregnancy
• Severe pruritus or pemphigoid gestationis
• Undiagnosed irregular vaginal bleeding
• Porphyria

Refer to the specific SPC for general and more specific contra-indications