The choice of antimalarial should be appropriate for the destination and current UK guidelines, taking into account:

1. Risk of exposure to infected bites
2. Patient specific factors i.e. pre-existing medical conditions/other medicines being taken/potential compliance to regime

Drug regimes currently recommended⁷ for malaria prophylaxis:  

• Chloroquine
• Chloroquine with Proguanil
• Atovaquone with Proguanil
• Doxycycline
• Mefloquine

Antimalarials do not prevent the infection, but kills the parasite in the blood cells (suppressive prophylaxis) or liver cells (causal prophylaxis).